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  • Chapter 4 The Central Dogma
    • 4-1 Introduction
    • 4-2 The DNA sequence directs the synthesis of proteins
    • 4-3 DNA Replication uses a collection of proteins called a replication complex
    • 4-4 After replication, the two copies of the chromosome move to opposite ends of the microbe
    • 4-5 Not all DNA in the prokaryotic cell is chromosomal: the specific case of plasmids
    • 4-6 Plasmids can vary in size and number
    • 4-7 Errors can occur in DNA replication that create potential mutations
    • 4-8 Errors in DNA can also occur outside of replication
    • 4-9 SOS repair can fix serious errors in the DNA, but is error prone
    • 4-10 Recombination repair can accurately fix large errors in the DNA
    • 4-11 There are more complicated mutations: deletions, duplications, and amplifications
    • 4-12 Mobile genetic elements can also cause mutations in the chromosome
    • 4-13 Genetic changes do not become fixed in the DNA until they are copied
    • 4-14 Transcription involves the copying of DNA into RNA
    • 4-15 The level of mRNA is a common regulatory point in prokaryotes
    • 4-16 Prokaryotic mRNAs are typically more than one gene long
    • 4-17 Differential transcription and stability of mRNA can also be used as points of regulation
    • 4-18 Translation is the conversion of mRNA into protein at the ribosome
    • 4-19 Translation is initiated at the Shine-Dalgarno sequence and involves formyl methionine (fMet)
    • 4-20 Some interesting facts about translation
    • 4-21 Chapter summary