Figure 8.7. A chemical reaction catalyzed by an enzyme. This animation is a simulation of the synthesis of acetyl-CoA by Carbon Monoxide Dehydrogenase and Acetyl-CoA Synthase. These reactions are part of the Wood–Ljungdahl pathway. In the first panel, set the amount of each substrate (Carbon Dioxide, CFeSP w/ Methyl, and Coenzyme A) using the sliders or the textbox. Click either one of the buttons (Start No Enzymes or Start with Enzymes) to observe the rate of acetyl-CoA synthesis. Note how increasing the concentration of substrate or adding enzymes increases the rate of reaction.